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Literature summary extracted from

  • Passi, A.; Vigetti, D.; Buraschi, S.; Iozzo, R.V.
    Dissecting the role of hyaluronan synthases in the tumor microenvironment (2019), FEBS J., 286, 2937-2949 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Homo sapiens Q92819
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2.4.1.212 Mus musculus P70312
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 Hs-578T cell MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7 Homo sapiens
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2.4.1.212 MCF-7 cell MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7 Homo sapiens
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2.4.1.212 MDA-MB-231 cell MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7. HAS2 is dramatically increased in bone metastases compared to the parental MDA-MB-231 cells Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 Has2
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 Homo sapiens
2.4.1.212 Has2
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 Mus musculus
2.4.1.212 hyaluronan synthases 2
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 Homo sapiens
2.4.1.212 hyaluronan synthases 2
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 Mus musculus

Expression

EC Number Organism Comment Expression
2.4.1.212 Homo sapiens MDAMB-231 and HS578T breast cancer cell line express higher levels of hyaluronan synthase 2 mRNA and synthesize higher amounts of hyaluronan than breast cancer cell lines with a less aggressive phenotype, like MCF-7 up

General Information

EC Number General Information Comment Organism
2.4.1.212 malfunction Has2-/- mice are embryonic lethal. Has2-/- embryos die between embryonic day 9.5 and 10.5 and exhibit severe cardiac and vascular abnormalities, in addition to yolk sac and somite deformities Mus musculus
2.4.1.212 physiological function enzyme expression has a pivotal role in cell motility and invasion. The enzyme regulates tumor progression and cell aggressiveness. Mammary tumor biopsies in which the enzyme (HAS2) is overexpressed display enhanced angiogenesis and inflammatory cells recruitment. HAS2 is a critical factor that induces epithelial-mesenchymal transition Homo sapiens